バイオ医薬品
バイオ医薬品分野では、タンパク質、ワクチンなどの繊細な生物由来材料の構造と活性を保持するために使用される、SINOTHERMOの真空・凍結乾燥設備を取り扱っています。低温真空処理により、これらの材料を変性させる熱ダメージを回避でき、パイロットスケールでの処方検討から生産バッチでの凍結乾燥まで幅広く対応します。
FZG-Static Vacuum Cabinet Dryer
カテゴリー: 伝導・真空乾燥機, 真空棚段式乾燥機
Vacuum Dryer with Pulse Back-Blow Function:
The Square Static Vacuum Dryer comes with spacious hollow heating tubes, warming materials on trays. It is perfect for operating at low temperatures in a vacuum, suitable for handling explosive and heat-sensitive materials while maintaining their original characteristics and properties.
- Input:
- Liquids, Slurries, Pastes and Thick Materials
- Output:
- Lump Solids with 3%-5% moisture content
- Temperature:
- Heat source temperature <100°C
DW-Belt Dryer
カテゴリー: 熱風乾燥機
Continuous Convection Dryer with Mesh Belt:
The Belt Dryer can be configured with single or multiple mesh-belt layers, spreading material evenly for directional hot-air drying. Belt speed adjusts to each material's temperature and moisture content, so it runs at comparatively low temperatures while continuously processing large batches.
- Input:
- Permeable solids in sheets, strips, granules or blocks
- Output:
- Sheet, strip, granule or block solids with 3%–8% moisture content
- Temperature:
- Inlet air temperature < 200°C
- Additional Feature:
- Cooling
FLP-Wurster Fluidized Bed Granulation Coater
カテゴリー: 造粒機・押出機, 流動層造粒機
All-in-One Mixing, Granulating, Coating, and Drying:
After the main material forms a fluidized bed at the bottom, granules are created with the aid of adhesive sprayed from the top nozzles in the granulating chamber. Subsequently, coating material is sprayed onto the granules from bottom or side nozzles within the chamber for effective coating.
- Input:
- Main ingredient as powder (for granulation) or granules and pellets (for coating), with adhesive or coating material in liquid form
- Output:
- Solid medium-sized granules with 3%–5% moisture content
- Type:
- Spray Fluidized Bed, Wet Granulation
- Additional Features:
- Mixing, Coating, Drying, Cooling
ZLG-Horizontal Vibrating Fluidized Bed Dryer
カテゴリー: 熱風乾燥機, 流動層乾燥機, 振動式乾燥機
Continuous Drying Solution for Granular Materials:
Operating on the principle of fluidization combined with vibration, the Vibrating Fluid Bed Dryer processes granules by circulating them on heated air that dries them evenly. This approach minimizes surface damage, prevents pollution thanks to its enclosed design, and gives granules time to settle — facilitating stable, continuous production.
- Input:
- Granules with moisture content < 20%
- Output:
- Granules with 1%–5% moisture content
- Temperature:
- Inlet air temperature < 200°C
- Additional Feature:
- Cooling
SET-Screw Extruder Granulator
カテゴリー: 造粒機・押出機
Wet Granulation with Screw Extrusion Process:
By utilizing an extrusion process, this wet-granulation machine leverages the self-viscosity of a solid-liquid dispersion to bond powder particles, producing granules of consistent shape and size. The screw-extrusion mechanism generates enough force to form pellets without always requiring a binder — particularly suitable for high-viscosity materials. Optional water cooling is available.
- Input:
- Solid-liquid mixture (predominantly solid)
- Output:
- Moist cylindrical granules
- Type:
- Extrusion Granulation, Wet Granulation
GHL-Wet Rapid Mixing Granulator
カテゴリー: 造粒機・押出機
Cutting-Edge Wet Granulation Technology:
A paddle at the base swiftly mixes powders and sticky binders within a cylindrical bowl, while a rapid chopper on the side breaks the mixture into wet granules to prevent clumping. This fast process combines mixing and granule formation within minutes, and the Wet Rapid Mixing Granulator can provide heating or cooling as needed.
- Input:
- Main material in powder form, binding agent as paste
- Output:
- Solid, loose granules with approximately 15% moisture content
- Type:
- Mixing Granulation, Wet Granulation
- Additional Features:
- Mixing, Mild Crushing, Heating, Cooling
GXP-Closed Circulation Spray Dryer
カテゴリー: 熱風乾燥機, スプレー乾燥機
Optimal Drying for Sensitive Materials:
This explosion-proof spray dryer operates in a sealed environment, using inert gas as the drying medium to fully recover solvents from raw materials. The recyclable drying medium provides superior protection for sensitive materials.
- Input:
- Solutions, Emulsions, Suspensions
- Output:
- Powder with 3%–8% moisture content
- Temperature:
- Inlet air temperature range of 100°C to 300°C
- Suitability:
- Anaerobic, explosion-proof and low-temperature conditions
ZLPG-Extract Spray Dryer
カテゴリー: 熱風乾燥機, スプレー乾燥機
Specialized Spray Dryer for Extracts:
The Extract Spray Dryer features a cylinder equipped with a cooling system specifically designed for drying extracts while keeping wall temperatures below 80°C. It includes an airbrush that cleans the walls during operation to prevent adhesion and protect the powder from burning.
- Input:
- Extracts (Liquid)
- Output:
- Extracts (Powder) with 3%–8% moisture content
- Temperature:
- Inlet air temperature range of 140°C to 180°C
- Additional Features:
- Freeze dehumidification, Air brush for tower cleaning
PGL-Fluidized Bed Spray Granulator
カテゴリー: 造粒機・押出機, 流動層造粒機
Combines Mixing, Granulating and Drying for High-Excipient Granulation:
Excipient-rich granulation finds an ideal match in this unit. Excipients in the hopper form a fluidized bed that acts as seeds or carriers, while the main material — typically a liquid extract making up a smaller proportion of the batch — is sprayed from above and merges at the bed's edge for granulation. This method is particularly suited to heat-sensitive materials.
- Input:
- Carrier materials in powder form, main material in liquid form
- Output:
- Solid medium-sized granules, 3%–5% moisture content
- Type:
- Spray Fluidized Bed, Wet Granulation
- Additional Features:
- Mixing, Drying, Cooling
ZYG-Vacuum Horizontal Disc Dryer
カテゴリー: 伝導・真空乾燥機
Vacuum Conduction Dryer with Hollow Disc Stirrers:
The Vacuum Horizontal Disc Dryer has a large-area jacket for heating and hollow disc stirrers that enhance the heating surface. It performs better than rake and paddle vacuum dryers in heating efficiency for many materials, is suited to low-temperature vacuum operation, and is ideal for handling flammable, explosive, organic-solvent-based and heat-sensitive materials.
- Input:
- Liquids, Slurries, Pastes, and Mashes
- Output:
- Powder with 3%–10% moisture content
- Temperature:
- Heat source temperature 50°C to 200°C
- Additional Feature:
- Stirring, Mild Crushing
Pilot Freeze Dryer
カテゴリー: 凍結乾燥機, 業務用凍結乾燥機, 実験室凍結乾燥機
Cutting-Edge Precision Freeze Drying Technology:
The Pilot Freeze Dryer stands out for its accuracy and precision, making it a crucial tool in sectors like pharmaceuticals, biotechnology and food processing. It upholds the chemical and structural integrity of products by drying them at low temperature under vacuum, and offers configurable shelf layouts to accommodate substances ranging from delicate biological materials to sturdy chemical compounds.
- Input:
- Liquids, extracts, blocks, slices, strips
- Output:
- Dehydrated liquids, concentrated extracts, dried blocks, slices and strips
- Temperature:
- Capable of achieving temperatures as low as -55°C
- Additional Feature:
- Defrost System
Benchtop Freeze Dryer
カテゴリー: 凍結乾燥機, 実験室凍結乾燥機
Compact Freeze Drying for Lab and Small-Scale Production:
The Benchtop Freeze Dryer brings full freeze-drying capability to a footprint that fits a lab bench or small production room. Automated controls streamline each cycle, while low-temperature vacuum drying preserves the structure and properties of pharmaceutical materials, biological specimens and food products — a dependable choice for drug and vaccine preparation, sample preservation and small-batch trials.
- Input:
- Pharmaceutical materials, biological specimens, food products
- Output:
- Freeze-dried product with preserved structure and properties
- Type:
- Laboratory / small-scale vacuum freeze drying
- Cold Trap:
- Down to -80°C
Round Freeze Dryer
カテゴリー: 凍結乾燥機, 業務用凍結乾燥機, 産業用凍結乾燥機
Maximize Output with Cylindrical-Chamber Freeze Drying:
The Round Freeze Dryer uses a cylindrical chamber that maximizes space usage for large-batch freeze drying at industrial scale. Built to handle big batches without compromising quality or efficiency, it helps companies expand freeze-drying capacity for pharmaceuticals, biological samples and food products while minimizing waste.
- Input:
- Pharmaceuticals, biological samples, food products (large batches)
- Output:
- Freeze-dried product with extended shelf life
- Temperature:
- Adjustable -50°C to -80°C
- Design:
- Cylindrical high-capacity chamber
繊細な生物由来材料のための穏やかな乾燥
FZG静置式真空箱型乾燥機、およびパイロット・卓上型・丸型凍結乾燥機は、低温真空乾燥によりタンパク質、ワクチンなどのバイオ医薬品の構造と活性を保持します。一方、GXP密閉循環式およびZLPGエキス・抽出物スプレー乾燥機は、溶媒に敏感なバイオ医薬品中間体の処理に対応します。
バイオ医薬品の厳しい加工要件への対応
低温真空下での凍結乾燥は、タンパク質構造と生物活性を保持するための標準的な方法です。 密閉循環式スプレー乾燥は、加工中に酸素や溶媒に敏感なバイオ医薬品中間体を保護します。 パイロットスケール設備は、生産スケールの凍結乾燥に移行する前の処方開発を支援します。
