Biologici

Il settore Prodotti biologici comprende le apparecchiature di essiccazione sotto vuoto e liofilizzazione di SINOTHERMO utilizzate per preservare la struttura e l'attività di proteine, vaccini e altri materiali biologici sensibili. La lavorazione sotto vuoto a bassa temperatura evita i danni termici che denaturerebbero questi materiali, coprendo dalle prove di formulazione in scala pilota fino alla liofilizzazione di lotti di produzione.

FZG-Essiccatore Statico a Vuoto a Vassoi

FZG-Essiccatore Statico a Vuoto a Vassoi

Categorie: Essiccatore a conduzione e sottovuoto, Essiccatore a Vassoi a Vuoto

Vacuum Dryer with Pulse Back-Blow Function:

The Square Static Vacuum Dryer comes with spacious hollow heating tubes, warming materials on trays. It is perfect for operating at low temperatures in a vacuum, suitable for handling explosive and heat-sensitive materials while maintaining their original characteristics and properties.

Input:
Liquids, Slurries, Pastes and Thick Materials
Output:
Lump Solids with 3%-5% moisture content
Temperature:
Heat source temperature <100°C
DW-Essiccatore a nastro

DW-Essiccatore a nastro

Categorie: Essiccatore a convezione

Continuous Convection Dryer with Mesh Belt:

The Belt Dryer can be configured with single or multiple mesh-belt layers, spreading material evenly for directional hot-air drying. Belt speed adjusts to each material's temperature and moisture content, so it runs at comparatively low temperatures while continuously processing large batches.

Input:
Permeable solids in sheets, strips, granules or blocks
Output:
Sheet, strip, granule or block solids with 3%–8% moisture content
Temperature:
Inlet air temperature < 200°C
Additional Feature:
Cooling
Ricopritrice a Granulazione a Letto Fluido Wurster FLP

Ricopritrice a Granulazione a Letto Fluido Wurster FLP

Categorie: Granulatore ed estrusore, Granulatore a Letto Fluido

All-in-One Mixing, Granulating, Coating, and Drying:

After the main material forms a fluidized bed at the bottom, granules are created with the aid of adhesive sprayed from the top nozzles in the granulating chamber. Subsequently, coating material is sprayed onto the granules from bottom or side nozzles within the chamber for effective coating.

Input:
Main ingredient as powder (for granulation) or granules and pellets (for coating), with adhesive or coating material in liquid form
Output:
Solid medium-sized granules with 3%–5% moisture content
Type:
Spray Fluidized Bed, Wet Granulation
Additional Features:
Mixing, Coating, Drying, Cooling
ZLG - Essiccatore a Letto Fluido Vibrante Orizzontale

ZLG - Essiccatore a Letto Fluido Vibrante Orizzontale

Categorie: Essiccatore a convezione, Essiccatore a Letto Fluidizzato, Essiccatore Vibrante

Continuous Drying Solution for Granular Materials:

Operating on the principle of fluidization combined with vibration, the Vibrating Fluid Bed Dryer processes granules by circulating them on heated air that dries them evenly. This approach minimizes surface damage, prevents pollution thanks to its enclosed design, and gives granules time to settle — facilitating stable, continuous production.

Input:
Granules with moisture content < 20%
Output:
Granules with 1%–5% moisture content
Temperature:
Inlet air temperature < 200°C
Additional Feature:
Cooling
Granulatore a Estrusore a Vite SET

Granulatore a Estrusore a Vite SET

Categorie: Granulatore ed estrusore

Wet Granulation with Screw Extrusion Process:

By utilizing an extrusion process, this wet-granulation machine leverages the self-viscosity of a solid-liquid dispersion to bond powder particles, producing granules of consistent shape and size. The screw-extrusion mechanism generates enough force to form pellets without always requiring a binder — particularly suitable for high-viscosity materials. Optional water cooling is available.

Input:
Solid-liquid mixture (predominantly solid)
Output:
Moist cylindrical granules
Type:
Extrusion Granulation, Wet Granulation
GHL-Granulatore a Miscelazione Umida Rapida

GHL-Granulatore a Miscelazione Umida Rapida

Categorie: Granulatore ed estrusore

Cutting-Edge Wet Granulation Technology:

A paddle at the base swiftly mixes powders and sticky binders within a cylindrical bowl, while a rapid chopper on the side breaks the mixture into wet granules to prevent clumping. This fast process combines mixing and granule formation within minutes, and the Wet Rapid Mixing Granulator can provide heating or cooling as needed.

Input:
Main material in powder form, binding agent as paste
Output:
Solid, loose granules with approximately 15% moisture content
Type:
Mixing Granulation, Wet Granulation
Additional Features:
Mixing, Mild Crushing, Heating, Cooling
Essiccatore Spray a Circolazione Chiusa GXP

Essiccatore Spray a Circolazione Chiusa GXP

Categorie: Essiccatore a convezione, Essiccatore Spray

Optimal Drying for Sensitive Materials:

This explosion-proof spray dryer operates in a sealed environment, using inert gas as the drying medium to fully recover solvents from raw materials. The recyclable drying medium provides superior protection for sensitive materials.

Input:
Solutions, Emulsions, Suspensions
Output:
Powder with 3%–8% moisture content
Temperature:
Inlet air temperature range of 100°C to 300°C
Suitability:
Anaerobic, explosion-proof and low-temperature conditions
ZLPG-Essiccatore Spray per Estratti

ZLPG-Essiccatore Spray per Estratti

Categorie: Essiccatore a convezione, Essiccatore Spray

Specialized Spray Dryer for Extracts:

The Extract Spray Dryer features a cylinder equipped with a cooling system specifically designed for drying extracts while keeping wall temperatures below 80°C. It includes an airbrush that cleans the walls during operation to prevent adhesion and protect the powder from burning.

Input:
Extracts (Liquid)
Output:
Extracts (Powder) with 3%–8% moisture content
Temperature:
Inlet air temperature range of 140°C to 180°C
Additional Features:
Freeze dehumidification, Air brush for tower cleaning
PGL-Granulatore Spray a Letto Fluidizzato

PGL-Granulatore Spray a Letto Fluidizzato

Categorie: Granulatore ed estrusore, Granulatore a Letto Fluido

Combines Mixing, Granulating and Drying for High-Excipient Granulation:

Excipient-rich granulation finds an ideal match in this unit. Excipients in the hopper form a fluidized bed that acts as seeds or carriers, while the main material — typically a liquid extract making up a smaller proportion of the batch — is sprayed from above and merges at the bed's edge for granulation. This method is particularly suited to heat-sensitive materials.

Input:
Carrier materials in powder form, main material in liquid form
Output:
Solid medium-sized granules, 3%–5% moisture content
Type:
Spray Fluidized Bed, Wet Granulation
Additional Features:
Mixing, Drying, Cooling
ZYG-Essiccatore a Disco Orizzontale sotto Vuoto

ZYG-Essiccatore a Disco Orizzontale sotto Vuoto

Categorie: Essiccatore a conduzione e sottovuoto

Vacuum Conduction Dryer with Hollow Disc Stirrers:

The Vacuum Horizontal Disc Dryer has a large-area jacket for heating and hollow disc stirrers that enhance the heating surface. It performs better than rake and paddle vacuum dryers in heating efficiency for many materials, is suited to low-temperature vacuum operation, and is ideal for handling flammable, explosive, organic-solvent-based and heat-sensitive materials.

Input:
Liquids, Slurries, Pastes, and Mashes
Output:
Powder with 3%–10% moisture content
Temperature:
Heat source temperature 50°C to 200°C
Additional Feature:
Stirring, Mild Crushing
Liofilizzatore Pilota

Liofilizzatore Pilota

Categorie: Liofilizzatore, Liofilizzatore Commerciale, Liofilizzatore da Laboratorio

Cutting-Edge Precision Freeze Drying Technology:

The Pilot Freeze Dryer stands out for its accuracy and precision, making it a crucial tool in sectors like pharmaceuticals, biotechnology and food processing. It upholds the chemical and structural integrity of products by drying them at low temperature under vacuum, and offers configurable shelf layouts to accommodate substances ranging from delicate biological materials to sturdy chemical compounds.

Input:
Liquids, extracts, blocks, slices, strips
Output:
Dehydrated liquids, concentrated extracts, dried blocks, slices and strips
Temperature:
Capable of achieving temperatures as low as -55°C
Additional Feature:
Defrost System
Liofilizzatore da banco

Liofilizzatore da banco

Categorie: Liofilizzatore, Liofilizzatore da Laboratorio

Compact Freeze Drying for Lab and Small-Scale Production:

The Benchtop Freeze Dryer brings full freeze-drying capability to a footprint that fits a lab bench or small production room. Automated controls streamline each cycle, while low-temperature vacuum drying preserves the structure and properties of pharmaceutical materials, biological specimens and food products — a dependable choice for drug and vaccine preparation, sample preservation and small-batch trials.

Input:
Pharmaceutical materials, biological specimens, food products
Output:
Freeze-dried product with preserved structure and properties
Type:
Laboratory / small-scale vacuum freeze drying
Cold Trap:
Down to -80°C
Liofilizzatore Rotondo

Liofilizzatore Rotondo

Categorie: Liofilizzatore, Liofilizzatore Commerciale, Liofilizzatore Industriale

Maximize Output with Cylindrical-Chamber Freeze Drying:

The Round Freeze Dryer uses a cylindrical chamber that maximizes space usage for large-batch freeze drying at industrial scale. Built to handle big batches without compromising quality or efficiency, it helps companies expand freeze-drying capacity for pharmaceuticals, biological samples and food products while minimizing waste.

Input:
Pharmaceuticals, biological samples, food products (large batches)
Output:
Freeze-dried product with extended shelf life
Temperature:
Adjustable -50°C to -80°C
Design:
Cylindrical high-capacity chamber

Essiccazione delicata per materiali biologici sensibili

L'essiccatore statico sottovuoto a armadio FZG e i Liofilizzatori Pilota, Da banco e Rotondi preservano la struttura e l'attività di proteine, vaccini e altri prodotti biologici attraverso l'essiccazione sotto vuoto a bassa temperatura, mentre gli essiccatori a spruzzo a circolazione chiusa GXP e per estratti ZLPG gestiscono intermedi biologici sensibili ai solventi.

Rispondere alle rigide esigenze di lavorazione dei prodotti biologici

La liofilizzazione sotto vuoto a bassa temperatura è il metodo standard per preservare la struttura proteica e l'attività biologica. L'essiccazione a spruzzo a circolazione chiusa protegge gli intermedi biologici sensibili all'ossigeno e ai solventi durante la lavorazione. Le apparecchiature in scala pilota supportano lo sviluppo della formulazione prima di passare alla liofilizzazione su scala produttiva.

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